Dr. James F. Collins


Dr. Collins' research interests include molecular mechanisms of intestinal iron transport, the influence of copper on iron homeostasis, nutrient-gene interactions (i.e. nutrigenomics), nutrient control of gene transcription, and iron absorption during inflammatory states (e.g. anemia of chronic disease).

Research Publications
  • Collins, J.F. (2015) Long noncoding RNAs and hepatocellular carcinoma. Gastroenterology. 148(2): 291-94.
  • Gulec, S., Anderson, G.J., Collins, J.F. (2014) Mechanistic aspects of intestinal iron transport. Am. J. Physiol. GIL Physiol. 307(4): G397-409.
  • Gulec, S., Collins, J.F. (2014) Molecular mediators governing iron-copper interactions. Ann. Rev. Nutr. 34: 95-116.
  • Gulec, S., Collins, J.F. (2014) Silencing the Menkes copper transporting ATPase (Atp7a) gene in rat intestinal epithelial cells increases iron flux via transcriptional induction of ferroportin 1 (Fpn1). J. Nutr. 144(2): 12-9.
  • Gulec, S., and Collins, J.F. (2014) Silencing of the Menkes copper-transporting ATPase (Atp7a) gene increases cyclin D1 protein expression and impairs proliferation of rat intestinal epithelial (IEC-6) cells. J. Trace. Elem. Med. Biol. 28(4): 459-64.
  • Jiang, L., Garrick, M.D., Garrick, L.M. Zhao, L., Collins, J.F. (2013) Divalent metal transporter 1 (Dmt1) mediates copper transport in the duodenum of iron-deficient rats and when overexpressed in iron-deprived HEK-293 cells. J. Nutr. 143(12):1927-33.
  • Xie, L., Collins, J.F. (2013) Transcription Factors Sp1 and Hif2a Mediate Induction of the Copper-Transporting ATPase (Atp7a) Gene in Intestinal Epithel;ial Cells During Hypoxia. J. Biol. Chem. doi:10.1074/jbc.M113.489500. Published online June 28, 2013.
  • Gulec, S., Collins, J.F. (2013) Investigation of Iron Metabolism in Mice Expressing a Mutant Menke’s Copper Transporting ATPase (Atp7a) Protein with Diminished Activity (Brindled; MoBr/y). PLOS ONE, 11;8(6):e66010. doi: 10.1371/journal.pone.0066010.
  • Xie, L., Collins, J.F. (2012) Copper stabilizes the Menkes copper-transporting ATPase (Atp7a) protein in rat intestinal epithelial cells. Am. J. Physiol. Cell Physiol., 304(3):C257-62
  • Lu, Y., Kim, C., Collins J.F. (2012) Multiple Menkes copper ATPase (Atp7a) transcript and protein variants are induced by iron deficiency in rat duodenal enterocytes. J. Trace Elem. Biol. Med. 26(2-3):109-14
  • Ranganathan, P.N., Lu, Y., Fuqua, B.K., Collins, J.F. (2012) Discovery of a cytosolic/soluble ferroxidase in rodent enterocytes. Proc. Natl. Acad. Sci. USA. 109(9):3564-9.
  • Ranganathan, P.N., Lu, Y., Fuqua, B.K., Collins, J.F. (2012) Immunoreactive Hephaestin and ferroxidase activity are present in the cytosolic fraction of rat enterocytes. Biometals. 25(4):687-95.
  • Klevay, L., Collins, J.F. (2011) Copper. Adv. Nutr. 2(6):520-22.
  • Jiang, L, Ranganathan, P.N., Lu, Y., Kim, C., Collins J.F. (2011) Exploration of the Copper Related Compensatory Response in the Belgrade Rat Model of Genetic Iron Deficiency. Am. J. Physiol. Gastrointest. Liver Physiol. 301(5):G877-86.
  • Ranganathan, P.N., Lu, Y., Jiang, L., Kim, C. Collins, J.F. (2011) Serum ceruloplasmin protein expression and activity increases in iron-deficient rats and is further enhanced by higher dietary copper intake. Blood. 118(11):3146-53.
  • Xie, L., Collins, J.F. (2011) Transcriptional regulation of the Menkes copper ATPase (Atp7a) gene by hypoxia-inducible factor (HIF2α) in intestinal epithelial cells. Am. J. Physiol. Cell Physiol. 300(6):C1298-305.
  • Hu, Zihua, Gulec, S., Collins, J.F. (2010) Cross-Species Comparison of Genome-Wide Gene Expression Profiles Reveals a Preferential Induction of Hypoxia Inducible Factor (HIF) Responsive Genes in Iron Deprived Intestinal Epithelial Cells. Am. J. Physiol. Cell Physiol.299:930-938.
Textbook Chapters:
  • Collins, J.F. (2011) Copper. In Modern Nutrition in Health and Disease, 11th Edition; Lipcott, Williams and Wilkins.
  • Kiela, P.R., Collins, J.F., Ghishan, F.K. (2011) Molecular Mechanisms of Intestinal Transport of Calcium, Phosphate and Magnesium. In Physiology of the Gastrointestinal Tract, 5th Edition. Academic Press.
  • Collins, J. F. and Anderson, G.J. (2011) Mechanisms of Intestinal Iron Absorption. In Physiology of the Gastrointestinal Tract, 5th Edition. Academic Press.

Associate Professor