Dr. Robin da Silva BSc. PhD.
The focus of Dr. da Silva’s lab is the interplay between metabolism and immune signaling in disease. Non-alcoholic fatty liver disease (NAFLD) is a prevalent condition around the world for which there are few therapeutic options. Inflammation associated with NAFLD can cause irreversible organ damage that can only be effectively treated by the invasive surgical techniques of liver resection and transplantation. Aberrations in one-carbon metabolism are present in NAFLD and dietary manipulation of the one-carbon pathway can be used to improve liver. In addition, conditions of nutrient and enzyme deficiencies that perturb one-carbon metabolism cause fatty liver, immune cell activation and organ damage. A more complete understanding of the cross-talk between metabolism and immune cell signaling is paramount to the design of new drugs and therapies to treat inflammation and disease.
Non-Alcoholic Fatty Liver Disease
HUN 6321 Fall