Chung, Soonkyu, Ph.D.
572 Newell Dr.
P.O. Box 110370
Gainesville, FL 32611-0370
Phone: 352-392-1991 ext. 229
- Ph.D. University of North Carolina at Greensboro; Nutrition, 2006
- M.S. Seoul National University; Agricultural Chemistry, 1994
- B.Sc. Seoul National University; Agricultural Chemistry,1992
Postdoctoral Fellow, Wake Forest School of Medicine; Pathology/Lipid Science, 2006-2010
Dr. Chung’s research interest focuses on lipid metabolism and signaling in adipose tissue: molecular mechanisms of brown-like adipocyte differentiation in human white adipose tissue, regulation of endocannabinoid system and gut microbiota by dietary polyphenols, and regional differences of ABCA1-dependent HDL biogenesis in adipose tissue and its impact on pathogenesis of obesity and insulin resistance.
HUN 6301: Nutritional Aspects of Lipids
HUN 6305: Nutritional Aspects of Carbohydrates
Lord C, Betters JL, Ivano PT, Milne SB, Madenspacher J, Chung S, Liu M, Davos MA, Lee RG, Crooke RM, Graham MJ, Parks JS, Brasaemle DL, Fessler M, Brown AH, Brown JM. CGI-58/ABH-derived signaling lipids regulate systemic inflammation and insulin action. Submitted 2011.
Chung S, Gebre AK, and Parks JS. Adipocyte ABCA1 contributes to the HDL biogenesis. Submitted 2011
Chung S, Degirolamo C, Rong S, Zhu X, Shelness GS, & Parks JS. Hepatic deletion of ABCA1 promotes hepatic inflammation and insulin resistance. Submitted 2011.
Obsen T, Faergeman NJ, Mandrup S, Chung S, Martinez K, Gobern S, Loreau O, Wabitsch M, and McIntosh MK. Trans-10, cis-12 conjugated Linoleic Acid Decreases de novo Lipid Synthesis in Human Adipocytes. In press J. Nutritional Biochemistry, 2011.
Jia L, Ma Y, Rong S, Betters JL, Xie P, Chung S, Wang N, Tang W, Yu L. Niemann-Pick C1-like 1 deletion in mice prevents high fat diet-induced fatty liver by reducing lipogenesis. J Lipid Res. 51: 3135-3144, 2010
Kennedy, A, Martinez K, Chung S, LaPoint K, West T, Hopkins R, Anderson K, Schmidt S, Mandrup S & McIntosh K. Inflammation and insulin resistance induced by trans-10, cis-12 Conjugated linoleic acid are dependent on intracellular calcium levels in primary cultures of human adipocytes. J Lipid Res. 51: 1906-1917, 2010.
Chung S, Timmins JM, Duong M, Degirolamo C, Rong S, Sawyer JK, Singaraja RR, Hayden MR, Maeda N, Rudel LL, Shelness GS & Parks JS. Targeted Deletion of Hepatocyte ABCA1 Leads to Very Low Density Lipoprotein Triglyceride Overproduction and Low Density Lipoprotein Hypercatabolism. J Biol. Chem. 285:12197-209, 2010.
Brown JM, Chung S, Sawyer JK, Degirolamo C, Alger HM, Nguyen T, Zhu X, Duong M, Brown AL, Shah R, Davis MA, Kelley K, Wilson MD, Parks JS, & Rudel LL. Combined Therapy of Dietary Fish Oil and Stearoyl-CoA Desaturase 1 (SCD1) Inhibition Prevents The Metabolic Syndrome and Atherosclerosis. Arterioscher Thromb Vasc Biol. 30: 24-30, 2010.
Chung S, Gebre AK, Seo J, Shelness GS, and Parks JS. A novel role for ABCA1-generated large nascent HDL in the regulation of VLDL triglyceride secretion. J Lipid Res. 51:729-742, 2010.
Brown JM, Chung S, Sawyer JK, Degirolamo C, Alger HM, Nguyen T, Zhu X, Duong M, Wibley AL, Davis MA, Kelly K, Wilson MD, Parks JS, Rudel LL. Inhibition of Stearyl-CoA 1 (SCD-1) dissociates Insulin resistance and obesity from atherosclerosis. Circulation, 118:1467-1475, 2008.
Mulya A, Lee JY, Gebre AK, Boudyguina K, Chung S, Smith TL, Colvin PL, Jiang X.C, and Parks JS. Initial interaction of ApoA-I with ATP Binding Cassette Transporter A1(ABCA1) impacts in vivo metabolic fate of nascent HDL. J Lipid Res, 49: 2390-2401, 2008.
Kennedy A, Chung S, LaPoint K, Fabiyi, O. & McIntosh, M. Trans-10, cis-12 Conjugated linoleic acid antagonizes ligand -dependent PPAR activity in primary cultures of human adipocytes. J. of Nutr. 138: 455-461, 2008.